Readable’s interface is available in English, French and Spanish, across 20 regional variants:

English
UK, US, Canada, Ireland, South Africa, Australia, New Zealand and India.
French
France, Canada, Belgium, Switzerland and Luxembourg.
Spanish
Spain, Mexico, Argentina, Chile, Colombia, the United States and Latin America.

Readable follows your Mac’s language. To change it, open System Settings β†’ General β†’ Language & Region; you can also set a language for Readable alone under Applications on that page.

The language Readable speaks depends on the voice you choose β€” see Choosing a Voice. Word prediction follows your Mac’s language and spelling preferences.